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Design of Aromatic-Containing Cell-Penetrating Peptide Mimics with Structurally Modified TT Electronics

An article by Brittany M. deRonde, Alexander Birke, and Gregory N. Tew* is featured in the February 9th issue of Chemistry - A European Journal.

Brittany M. deRonde et al. developed a series of ROMP-based cell penetrating peptide mimics (CPPMs) using monomers that contained aromatic rings substituted with electron-donating and electron-withdrawing groups, covering an electrostatic potential range from −29.69 to +15.57 kcal mol−1. Results indicated that the strength of the electron-donating and electron-withdrawing groups incorporated in the CPPMs did not alter the polymers’ abilities to interact with lipid membranes. This opens up a wide range of aromatic groups that can be incorporated into CPPMs for structural tuning without negatively impacting polymer membrane activity.

Chemistry - A European Journal    

February 18, 2015